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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-509-3-5p
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM cell line OCM‐1A; human embryonic kidney cell line HEK293T
Methods qPCR, Western blot, transfection, proliferation assay, transwell assay, wound healing assay, luciferase reporter assay
Expression pattern down-regulated
Functional description The findings of the presents study demonstrated that the miRNAs of the miR-506-514 cluster, hsa-miR-592 and hsa-miR-199a-5p were the most deregulated miRNAs in patients with high-grade disease compared to those with low-grade disease and were strictly related to the overall survival (OS) of the patients.
PubMed ID 30816460
Year 2019
Title Prognostic significance of deregulated microRNAs in uveal melanomas.
Drug-related ncRNA NO

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